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pentobarbital will lessen the extent or influence of diazepam buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Powerful or moderate CYP3A4 inducers may raise level of diazepam elimination; hence, efficacy of diazepam may be lessened.pentobarbital will decrease the extent or outcome of methylprednisolone by impac